Hi Lindsay,
You need to have a cost or wholesale price stored in a metafield on the product variant. Then you can tell Edit Orders to base the price on that - or a calculation of that.
You can also use a sales minus model. Example: your wholesale orders will be invoiced at sales price minus 30%.
Edit Orders is very flexible and there are several ways to make it work. If you could describe how you want to handle it and if you already have metafields, then I help you better :)
/Kim
Morfars.dk